منابع مشابه
Energetics of protein–DNA interactions
Protein-DNA interactions are vital for many processes in living cells, especially transcriptional regulation and DNA modification. To further our understanding of these important processes on the microscopic level, it is necessary that theoretical models describe the macromolecular interaction energetics accurately. While several methods have been proposed, there has not been a careful comparis...
متن کاملEnergetics of ion-protein interactions
In keeping with the goals of our laboratory, efforts in this thesis are directed towards improving our understanding, and therefore our ability to calculate, the energetics of protein-ligand interactions. Electrostatic contributions to protein-ligand binding events are poorly understood, and underrepresented in data sets used to parameterize the energetics of protein unfolding and binding. Ther...
متن کاملClassification and energetics of the base-phosphate interactions in RNA
Structured RNA molecules form complex 3D architectures stabilized by multiple interactions involving the nucleotide base, sugar and phosphate moieties. A significant percentage of the bases in structured RNA molecules in the Protein Data Bank (PDB) hydrogen-bond with phosphates of other nucleotides. By extracting and superimposing base-phosphate (BPh) interactions from a reduced-redundancy subs...
متن کاملProtein folding in membranes: determining energetics of peptide-bilayer interactions.
Although the problem of the folding of soluble proteins continues to resist solution, we at least have a strong understanding of the general thermodynamic principles1,2 and have available a wealth of thermodynamic data.3-5 The study of membrane protein folding and stability is much less advanced: Some general principles are emerging,6-9 but the amount of thermodynamic data available remains qui...
متن کاملFolding in Membranes: Determining Energetics of Peptide–Bilayer Interactions
Although the problem of the folding of soluble proteins continues to resist solution, we at least have a strong understanding of the general thermodynamic principles1,2 and have available a wealth of thermodynamic data.3-5 The study of membrane protein folding and stability is much less advanced: Some general principles are emerging,6-9 but the amount of thermodynamic data available remains qui...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2007
ISSN: 1362-4962,0305-1048
DOI: 10.1093/nar/gkl1103